Day 1: Thursday, June 13th 2019
9:00-10:00 Registration
10:00-10:10 Welcome speech
10:10-13:25 SESSION 1 Nucleic acids as drugs and biomarkers (chair Ramón Eritja)
10:10-10:55 Applying the chemist's toolbox to gene silencing and gene editing technologies. Masad Damha (invited speaker)
10:55-11:15 DNA-based nanoscaffolds as carrier of 5-fluoro-2'-deoxyuridine oligomers in colorectal cancer therapy. Carme Fàbrega
11:15-11:45 COFFEE BREAK
11:45-12:05 Inhibition of replicative stress genes WEE1 and CHK1 using Polypurine Reverse Hoogsteen Hairpins. Eva Aubets
12:05-12:25 MicroRNA sensors based on gold nanoparticles functionalized with oligonucleotides- Catarina Coutinho
12:25-12:45 Non-coding RNAs carried by gold or magnetic nanoparticles for the treatment of rare diseases. Paula Milán
12:45-13:05 Activation of transposable elements as biomarkers of neuroimmune disease. Elisa Oltra
13:05-13:25 2shRNA: A promising approach for multi-targeted treatment of cancer. Montserrat Terrazas
13:30-15:00 LUNCH
15:00-18:15 SESSION 2 Nucleic acids as targets (chair Federico Gago)
15:00-15:45 Modulation of RNA Biology in Human Disease with Small Molecules Razvan Nutiu (invited speaker)
15:45-16:05 G-quadruplex DNA as target in cancer and parasites: ligands based on carbohydrate naphthalene diimide conjugates. Juan Carlos Morales
16:05-16:25 A multidimensional approach to combat ALS. Miguel Garavís
16:25 - 16:55 COFFEE BREAK
16:55-17:15 Discovering novel HIV inhibitors that interfere with RRE-Rev complex formation. Cristina Medina-Trillo
17:15-17:35 Structural studies of i-motifs/duplex junctions and their complexes with small ligands. Israel Serrano
17:35-17:55 (F)uridylated Peptides Linked to Vpg1 of Foot-and-Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-dependent RNA polymerase. Sonia de Castro
17:55-18:15 DNA photostability vs photoreactivity: A quantum-chemistry standpoint. Daniel Roca
18:15-18:45 Discussion and election of site for XIII RANN
21:00-23:00 CONFERENCE DINNER
Day 2: Friday, June 14th 2019
9:00–12:55 SESSION 3 Modified Nucleosides, Nucleotides and Nucleic Acids (chair Miguel Ferrero)
9:00-9:45 Harnessing the Power and Potential of Palladium Catalysis for the Synthesis of Chemically Modified Nucleosides. Yogesh S. Sanghvi (invited speaker)
9:45-10:05 Engineering DNA-based nanostructures for bioimaging and biomimetics. Silvia Hernández-Ainsa
10:05-10:25 Bioconjugation reactions involving 1,2,4,5-tetrazines. Jordi Agramunt
10:25-10:45 Oligonucleotide-Based Therapy Targeting MicroRNAs in Myotonic Dystrophy. Arturo López
10:45-11:05 Photoinduced oxidation and reduction ring splitting of bipyrimidine-derived azetidines: a multifaceted approach. Virginie Lhiaubet-Vallet
11:05-11:35 COFFEE BREAK
11:35-11:55 Pro-cNMPs as novel chemical tools for cell-based assays. Chris Meier
11:55-12:15 A nanoparticle-based ligand for CuAAC fluorogenic "click" reactions in water. Ciro Rodríguez Díaz
12:15-12:35 Correction of point mutations of the aprt gene in mammalian cells by Repair-PolyPurine Reverse Hoogsteen hairpins. Álex J. Félix
12:35-12:55 Fluorescent derivatives for the detection and stabilization of i-motifs. Bartomeu Mir
13:00-14:30 LUNCH
14:30-16:15 SESSION 4 Advances in Nucleic Acids structure and function (chair Carlos González)
14:30-15:15 Advances in structural mass spectrometry to study nucleic acids folding and ligand interactions. Valérie Gabelica (invited speaker)
15:15-15:35 Atomistic insight into sequence-directed DNA bending and minicircle formation propensity in the absence and presence of phased A-tracts. Alberto Mills
15:35-15:55Functional mechanism of the 3'X RNA domain of hepatitis C virus. José Gallego
15:55-16:15 Solution equilibria of a guanine-rich sequence near the promoter region of the SMARCA4 gene. Raimundo Gargallo
16:15-16:20 Closing speech
Practicalities
Conference venue:
Sede de San Juan y San Vicente
Universidad Católica de Valencia
C/ Jorge Juan 18, Valencia
The conference hall is on the 1st floor
Coffees will be held next to the conference hall
Lunches will be taken at the conference's venue, 5th floor
The conference dinner will be at Restaurante Mosaico
C/Isabel La Católica 22 (3 minutes walking from the conference venue)